It takes two hours and leaves Chorlton Street at noon, arriving Birmingham Queensway at 2pm, giving you plenty of time to get over to Birmingham New Street train station and catch a quick train to Witton station, where Villa Park is.
There's no Megabus back, but you can get a one-way train ticket from New Street to Manchester for £8.50 in advance from The Train Line - so you can get there and back for £11.50.
As many reds will tell you, in previous years at Villa - especially with evening kick offs - British Transport Police have kindly kept a Manchester-bound train waiting for fans at New Street for the journey home once they arrive from Witton.
Aand there's usually no conductor checking for tickets back to Manchester. BUT it's your own risk.
Or, you can stay stick about, get a 10-minute train to Birmingham International and fly out to Reus on Ryanair at 6.30am on Sunday for £28.06 single in time for the following Tuesday's game at Villareal.
You can then fly back from Barcelona Girona to Manchester the day after the match for £8.09, again on Ryanair.
The flight prices do not include a booking fee (£4 per flight unless you use a Visa Electron) or baggage.