From Monday, applications will be taken for tickets for the short journey to Blackburn on Saturday October 4.
United have got 7,000 tickets, priced £35 adults, £25 over 65's and £15 under 16's.
From 8am on Monday to 8pm on Friday, executive members can apply by post or on 0161 868 8000 (select option 1) and speaking to an advisor.
Then from 8am on September 22 to 8am on September 24, season tickets who go to the Villarreal home game on Tuesday can apply online or by callling 0161 868 8000 (select option 1 twice).
Ballot results will be available from September 25.
The club is offering coach travel to the match, which costs £16 per person and leaves the N2 car park at 3pm, due to return to Old Trafford at 8.30pm.
To book, call 0161 868 8000 option 1 and speak to an advisor.